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Products

Preclinical

Opticho M

Opticho M

Photoacoustic dermatological imaging device

Photoacoustic microscopy (PAM) is a powerful imaging technique that visualizes optically sensitive structures deep within biological tissues. In both preclinical and clinical settings, real-time imaging is crucial for detecting specific disease markers. However, conventional PAM systems are often limited by their slow motorized scanning stages.

OptichoM introduces a high-speed, high-SNR PAM system powered by an advanced photoacoustic scanner. Its ability to scan in water enables simultaneous transmission and reflection of both ultrasound and laser signals, enhancing imaging efficiency. The system confocally aligns the laser and ultrasound beams to rapidly scan samples. When combined with a motorized stage, this hybrid PAM system achieves a wide scanning range with high-speed acquisition in both optical resolution (OR) and acoustic resolution (AR) modes.

In addition, we offer customizable systems that can be integrated with other optical and acoustic imaging modalities, such as ultrasound microscopy, OCT, and fluorescence imaging.

Applications

Vascular structural imaging, hemoglobin oxygen saturation

Tumor angiogenic or anti-angiogenic drug response

Tumor progression and regression monitoring

Ischemic diseases

Dermatological diseases

Structural and functional neuroimaging

Ocular imaging

Regenerative medicine

Label-free histology

Molecular imaging using contrast agents

Advantages

Switchable optical and acoustic resolution modes

Ultrasound microscopy mode

High-speed imaging capability

Excellent signal-to-noise ratio

Wide field of view imaging

Optimized user interface

Compact system size

Suitable for both animal and human experiments

Custom-built and multimodal systems are available (OCT, fluorescence, etc.)

OptichoM Specifications

Optical resolution Acoustic resolution
Lateral resolution ~2.5 - 10 μm ~80 - 150 μm
Axial resolution ~2.5 - 10 μm
B-scan speed1 1-400 Hz
Field of view2 ~ 30 x 30 mm² + More
Penetration depth ~ 1 mm in live animals
~ 0.5 mm in humans		 ~ 2.5 mm in live animals
~ 2 mm in humans
Applications Animals and humans
Accessories
  • Optical fiber coupling optics
  • Motorized sample stage (vertical)
  • 3D rendering software included
  • 1 The B-scan speed depends on the step size and pulse repetition rate of the laser.
  • 2 Reconstructed by stitching multiple images

OptichoM System Configuration

Main OptichoM Components

Water-immersible PA galvanometer scanner

Linear motorized stages

Ring US transducer (Fc: 20 MHz)

Opto-acoustic alignment module

Digitizer (12bit, 500 MHz)

Pulse laser

Pulse laser
Wavelength 532 nm
Pulse repetition rate Single shot to 100 kHz
(Best at 50 kHz)
Output power 5W
Pulse width 2 ~ 10 ns
Beam quality (M2) <1.6

OptichoM Demo Movie

OptichoM Gallery

In vivo optical-resolution photoacoustic imaging of a mouse

Mouse ear

Mouse brain

Mouse eye

J. Kim, et al., Light Science & Applications, Vol. 8, 103 (2019)
J. Park, et al., PNAS 118, e1920879118 (2021)

Real-time monitoring of blood perfusion in human fingers (optical-resolution)

J. Ahn, et al., Photoacoustics Vol. 23, 100282 (2021)

Super wide-field imaging of human hands (acoustic-resolution)

J. W. Baik et al., IEEE Transactions on Medical Imaging Vol 39, 975 (2020)

Whole-body PA imaging of a mouse

J. W. Baik et al., IEEE Transactions on Medical Imaging Vol 39, 975 (2020)

Whole-body PA and US imaging of a mouse

J. Ahn et al., Biosensors Vol 15, 200 (2025)